Rapidly Progressive Glomerulonephritis

Rapidly Progressive Glomerulonephritis are a group of renal diseases which are still posing serious threat to human health and survival. They are all characterised by acute and rapid deterioration of renal function. Renal biopsy reveals extracapillary glomerulonephritis, most frequently circumferential and diffuse, and immunofluorescence findings continue to represent the most important clue toward precise diagnosis. In the last years, with the development of new technologies and more targeted animal models, several discoveries have been made, that can help in better understanding the pathogenesis and perspectively defining new molecular targets for novel therapies, which are still required to improve the prognosis of these patients.